Molecular & structural biologist CNRS with a big respect for Transcription Factors, RNA Pol II & Mediator
#CryoEM #ESR
Advocating for #basicresearch #womeninSTEM #preprint
Message in English or French.
https://bsi-lille.cnrs.fr
Alexis Verger 🧬🧫🧪
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"bacteriophages devised their own compact sgRNAs tailored to subvert Cas9 immunity, long preceding their rational design to program RNA-guided nucleases" #CRISPR 🤯
[review]Transcription factors as drivers of 3D enhancer-promoter interactions
www.sciencedirect.com/science/arti...
Cryo-EM: the revolution continues doi.org/10.1107/S205...
Opposing roles of serine and charge in IDR condensate miscibility www.nature.com/articles/s41...
A #CRISPR based tool (Cas12a2) that can target specific cells based on a recognised transcript
To me, this looks like a very powerful tool for sequence-specific depletion of pathogenic cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...
Not wanting to be snarky but this is true of every technological advance in science. My entire PhD in 1983 was the fitting and refinement of a single protein crystal structure. Today I could do the same within an hour - no AI required.
Hyperbole does not help.
Les magistrates et magistrats travaillent en sous-effectif, dans des conditions lamentables. Je trouve insupportable qu'iels soient mis en cause par leur propre ministre. Il faut rappeler qu'ils ont un devoir de réserve et ne peuvent pas s'exprimer en retour.
www.lemonde.fr/societe/arti...
Excited to share the first pre-print from our lab!!
Check it out here! www.biorxiv.org/content/10.6...
We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.
Excited to share our new paper @nature.com! We developed PerturbFate, a scalable single-cell platform to discover how diverse genetic perturbations converge on a shared drug-resistant cell state, and key programs driving it, led by our incredible Zihan Xu from @rockefeller.edu
rdcu.be/fdC14
Video
Une intense pression politique pèse sur le petit palais de justice depuis la découverte du corps de la collégienne, le 4 juin. Alors que des inspecteurs sont attendus, des avocats qui fréquentent la p...
Pei, Wang, Quan and Geng and colleagues reveal how amino acid composition within intrinsically disordered regions influences the miscibility of biomolecular condensates and their function. Serine and ...
Nature - Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
www.nature.com
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Mir Lab
Laurence Pearl 🔥
Charlotte Truchet
Jon Henninger
Artificial intelligence systems will allow a single PhD student’s output to match that of a whole laboratory, according to Demis Hassabis, a Nobel laureate for chemistry.
