...and on our work demonstrating that chronic chemogenetic excitation of striatal cholinergic interneurons causes motor behavior in mice similar to quantifiable #dystonia in young people with #cerebralpalsy. doi.org/10.1002/ana.... 4/x
doi.org
Objective
Mouse models of genetic dystonias have demonstrated abnormal striatal cholinergic interneuron excitability, but do not consistently demonstrate subjective dystonic features. To determine w.....