Check out how we exploit observations of homology from evolution to design enhancers, even when we don't have prior knowledge or ability to specify function!
EnhancAR: Use evolution and deep learning to design enhancers with desired expression profiles!
Had a lot of fun working with Andrew Duncan, Micaela Consens @alexijie.bsky.social @lcrawford.bsky.social Jennifer Mitchell and Alan Moses!
www.biorxiv.org/content/10.6...
