Evolutionary Systems Biologist @ SILS University of Amsterdam
https://www.meikewortel.com/
Meike Wortel
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As a side result, we found that Roseburia intestinalis doesn't grow at all in most of the supplemented supernatants, a surprising finding that we cannot fully explain...
Next we predicted growth of co-cultures of up to four species with a gLV model, and experiments show that these predictions are quite accurate:
But what happens when a species invades a co-culture of other species? We predicted in which co-cultures E. coli and B. ovatus could invade, and showed that these predictions are accurate:
To assess their interactions, we compared the growth of species in fresh medium to supplemented supernatant of other species (similar to @lizscurious.bsky.social, @saramitri.bsky.social and others have done before):
E. coli and B. ovatus have quite different characteristics: E. coli grows fast but is negatively affected by other species, while B. ovatus is not such a fast grower but positively affected by others. B. ovatus was more likely to invade and in general interactions by other members support invasions:
All details can be found in the published version of the paper: doi.org/10.1128/msys... .
Great to see this out! doi.org/10.1093/evle.... Lead by
@karenbisschop.bsky.social
and Thomas Blankers. It discusses: If you repeat 𝐭𝐡𝐞 𝐬𝐚𝐦𝐞 𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐚𝐫𝐲 𝐞𝐱𝐩𝐞𝐫𝐢𝐦𝐞𝐧𝐭 𝐚𝐭 𝐝𝐢𝐟𝐟𝐞𝐫𝐞𝐧𝐭 𝐢𝐧𝐬𝐭𝐢𝐭𝐮𝐭𝐞𝐬, do you get the same result in terms of fitness? The answer is… not necessarily. Glad to have played a part!
Meike Wortel
Meike Wortel
Meike Wortel
Meike Wortel
Meike Wortel
Abstract. The repeatability of evolution is fundamentally important for understanding the origin and diversification of life as well as for developing evol
The stability of the human gut microbiome is crucial for host health, with opportunistic
pathogen invasions causing diseases and healthy strain replacements needed for recovery.
The microbiota’s compl...
