🚨 Preprint alert! 🚨
We showed the transient binding and supramolecular complexation between hyaluronan and polypeptides using a suite of techniques (NMR, SHS, DLS, and MD) across a broad concentration range, including *for the first time* the submicromolar regime.
Even at ultra-low concentrations, hyaluronan engages in multivalent, dynamic, and selective interactions—precisely the kind of behavior expected of the glycocalyx, largely shaped by hyaluronan.
I’m intentionally not including links or names. Instead, I challenge you to reflect on what might unfold in Europe and its neighboring regions in the near future.
If you usually avoid political discussions and only follow global events passively (or not at all) I still encourage you to catch up on recent developments, especially those of the past few weeks and today. Share your thoughts with friends, colleagues, or anyone in your circle.
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🚨 All right, since this is a place of sanity now, let’s kick things off with an open PhD position in my team to work on simulating glycans and their interactions. If you’re passionate about computational biophysics and glycobiology, go ahead and apply! Any shares would be greatly appreciated. 🙃
While NMR was limited to higher concentrations, SHS proved ideal for probing these subtle interactions, and MD simulations offered crucial mechanistic insight. Check the preprint for more details!
www.biorxiv.org/content/10.1...
The work became possible thanks to
@iocbprague.bsky.social, @ceitec.eu, and collaborators from #EPFL and Gdansk.
If you're interested in recent work we've been doing, take a look at these:
doi.org/10.1021/acs....
doi.org/10.1021/acs....
doi.org/10.1016/j.ca...
A big thanks also to my long-time collaborator and friend @denysbiriukov.bsky.social, who served as an internal peer-reviewer for the simulation part of the work ☺️
