We study the spatial organization of the nucleus across the cell cycle and how this safeguards genome stability. Located at Knight Cancer Institute, Oregon Health and Science University
Joshua Saldivar
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Interested in studying nuclear condensates across the cell cycle? Our latest methods paper in STAR Protocols may be exactly what you are looking for! Here, we describe a high-throughput, novel imaging approach that tracks condensate dynamics in human cells.
www.sciencedirect.com/science/arti...
Excited to share a new preprint from the lab by @melissamcevoy.bsky.social
The S/G2 checkpoint prevents the premature shutdown of the DNA replication program. Without it, cells fail to finish replicating their chromosomes and have severe mitotic errors.
www.biorxiv.org/content/10.6...
This work uncovers a G2-to-G0 cell cycle exit underlying the response to ATR inhibition.
New preprint out today from the lab! congrats to Celina Sanchez on this exciting work! check it out:
www.biorxiv.org/content/10.6...
Geneticist J. Craig Venter, best known for his role in sequencing the human genome, has died aged 79.
He spoke to Nature in 2023 about AI, sequencing the ocean – and why he had no plans to stop working.
go.nature.com/4d4h1ns
Now online! DNA repair drives cisplatin-induced neuronal death
such a surreal experience visiting my alma mater 25 years later to give a seminar and meet the faculty and grad students. @uarkansas.bsky.social
Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7)
www.cell.com/cell/fulltex...
Joshua Saldivar
Joshua Saldivar
Joshua Saldivar
Happy to share our new review in @annualreviews.bsky.social on abasic sites and their impact on DNA replication written by @angelotaglialatela.bsky.social.
www.annualreviews.org/content/jour...
Here is our article published in Nature Comm, on new players in chromatin dynamics after UV repair. This work highlights the histone chaperones DNAJC9 and MCM2 as central players in chromatin repair. Our proteomic dataset opens up new perspectives for dissecting epigenome maintenance mechanisms.
Melissa McEvoy
Joshua Saldivar
Nature
Apurinic/apyrimidinic (AP) sites, also known as abasic sites, are among the most frequent DNA lesions, arising spontaneously or as intermediates in base excision repair. Their structural impediment to...
Chromatin states need to be maintained during DNA damage repair. Here, the authors expand the histone chaperone network involved in repair-coupled chromatin restoration and highlight a mechanistic coo...
Transcription condensates are dynamic, phase-separated compartments that control gene activation. Here, we present a protocol for studying transcripti…
The human genome ‘maverick’ talks sequencing the ocean, setting up a health-screening company after checking his own genes — and why he has no plans to stop.
