🎉 Congratulations to the first authors, Priyanka Aggarwal and Manmohan Sharma!
Their study in the laboratory of Prof. Karl-Peter Hopfner provides important #mechanistic insight into #chromatin #remodeling across diverse #nucleosomalstates. 🧬🔬 #NARbreakthrough #Chromatin #Epigenetics #INO80
When art meets science! 🤩
Check out Drew's stunning animation of the cellular machinery behind homologous recombination — featuring our favorite DNA repair complex MRN, and other DNA repair heroes! 🧬🔧 @drewberry.bsky.social
🧐Curious about what has happened at the Gene Center over the past 5 years? Take a look at our hot-off-the-press report.🤩
www.genzentrum.uni-muenchen.de/institute/ab...
Hopfner Lab
Nucleic Acids Research
📣Publication alert: Julian Stingele and his team show that the chemotherapeutic drug azacitidine damages RNA and reveal a possible approach to improve therapies🤩👏
www.sciencedirect.com/science/arti...
@jstingele.bsky.social @lmu.de @shubozhao.bsky.social
📣Publication alert!
A team led by Roland Beckmann shows: Ribosome collisions activate the kinase ZAK and thus trigger the ribotoxic stress response — a key mechanism of the cellular stress defense. More about it here👇
www.lmu.de/en/newsroom/...
Gene Center Munich @LMU Munich
Gene Center Munich @LMU Munich
Gene Center Munich @LMU Munich
Check out our paper on nucleosome positioning by our favorite remodeler INO80 in a collaboration with the Bartholomew Lab, finally out in MolCell 🧬
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Excited to share our latest contribution in a collab with Helle Ulrich's Lab. Great work by Ronald and Mariia! Thanks to @sfb1361.bsky.social and @imbmainz.bsky.social 🧬🔨
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
We are excited to share our latest cryo-EM study of the human INO80 remodeler, now featured as a Breakthrough article in NAR @narjournal.bsky.social Check it out here and a big shoutout to @priyanka-pdm.bsky.social and Manmohan et al. for their contributions! 🧬
Hopfner Lab
Hopfner Lab
Hopfner Lab
Hopfner Lab
Hopfner Lab
⭐NAR Breakthrough! ⭐
🧬 New #cryo-EM work shows the #humanINO80 motor adapts to DNA unwrapping and can remodel altered particles like #hexasomes - highlighting its versatility across #nucleosome states. 🔬✨ @lmu.de @genecenter-lmu.bsky.social
Read the full article here: doi.org/10.1093/nar/...
Nucleic Acids Research
kwnsfk27.r.eu-west-1.awstrack.me
📣Publication alert!
Collaboration between Bartholomew lab and @hopfnerlab.bsky.social shows that INO80 positions nucleosomes at specific genomic sites by sensing intranucleosomal DNA shape and stalling at rigid DNA via its Arp5 subunit.
authors.elsevier.com/c/1m9kd3vVUP...
@mdanderson.bsky.social
Loving @drewberry.bsky.social's beautiful animation of DNA break repair by HR - featuring the MRN complex architecture and function inspired by the research from @hopfnerlab.bsky.social!
Dive into the science behind it🧬
www.sciencedirect.com/science/arti...
www.nature.com/articles/s41...
New publication!! 📑
Congrats to the Ulrich and @hopfnerlab.bsky.social labs on their latest work exploring how the INO80 chromatin remodeller facilitates DNA damage bypass via postreplicative gap repair.
🔎Read the paper here:
www.embopress.org/doi/full/10.1038/s44318-025-00580-4
Video
Gene Center Munich @LMU Munich
SFB1361
SFB1361
www.sciencedirect.com
Excessive RNA damage activates cellular stress responses, triggering cell death. However, pathways that negatively regulate RNA damage responses are l…
