Yours truly is a proper scientist now!
TL;DR: we used AI to redesign parts of essential cell machinery with only 19 canonical amino acids instead of 20.
Why? Great thread by @harriswang.bsky.social provides more context and details.
Let me talk a bit about the AI design part of this. 1/
Simon Kozlov
1/ Excited to share our new paper in Science @science.org: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” A great collab w/ Sergey's group @sokrypton.org at MIT
@columbiasysbio.bsky.social science.org/doi/10.1126/... 🦠🧬🛠️🖥️💥
Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...
