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The first draft of the human genome turns 25 today! 🎂 On 26 June 2000, the UK & US announced the first full map of the 3 billion DNA base pairs that make us human. 🌍 A milestone for humanity, powered by global collaboration. www.youtube.com/watch?v=pnWA... #HumanGenome #ScienceHistory 🖥️🧬

11mo

This a really exciting leap forward for genomic sequence to activity gene regulation models. It is a genuine improvement over pretty much all SOTA models spanning a wide range of regulatory, transcriptional and post-transcriptional processes. 1/

Our AlphaGenome paper and models are out today! 🧬 I'm really excited to see how people use the model and build on top of it in their biology research🔬 Huge congratulations to the entire team!👏 Read the full paper and access the model: 📄 Paper: goo.gle/4bXlV6y 💻 Code: goo.gle/4k1xrzI

11mo

4mo

EMBL-EBI

Highlighting two manuscript additions: 1. Data ablation (Supp. Fig 12): RNA-seq + ATAC/DNase proved essential for key evals. h/t @anshulkundaje.bsky.social for the suggestion! 2. Variant Analysis: We found evidence to upgrade a 3’ UTR VUS from Ellingford et al 2022 to "likely pathogenic."

Finally, huge congratulations to the amazing team behind this work! 👏

4mo

AlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

4mo

Anshul Kundaje

4mo

Žiga Avsec

Excited to launch our AlphaGenome API goo.gle/3ZPUeFX along with the preprint goo.gle/45AkUyc describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind

11mo