Assistant Professor, University of Washington, Genome Sciences.
Previous: JSMF Fellow, Berkeley EECS
♡: Computational biology, evolutionary dynamics, quantitative immunology
https://dewitt-lab.github.io/
[disclaimer: opinions mine] 🇺🇸🚫👑
William DeWitt
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We urge GSA members and the genetics community to submit a public comment on the recently proposed OMB regulations—which pose drastic challenges to the scientific enterprise—by July 13, 2026! Submit your comments here: www.regulations.gov/document/OMB...
I've learned a lot from this community at various meetings since I was a PhD student. I'm looking forward to this one!
William DeWitt
Genetics Society of America
Antibody LMs learn what looks antibody-like, but not how selection turns naive germline antibodies into strong binders.
@aakarshv1.bsky.social and I are excited to share CoSiNE, a model that learns this germline-to-mature process for variant effect prediction and antibody design. (1/8)
This was one of the most complex projects I have ever been involved in. Took us the better part of a decade, but I thoroughly enjoyed every minute of it. Especially the intensive and extensive interactions with @wsdewitt.github.io, @matsen.bsky.social, and @tylernstarr.bsky.social
...especially @tylernstarr.bsky.social for the deep mutational scan (DMS). This crucial genotype-phenotype map enabled us to understand GC evolutionary dynamics at the level of evolving molecular phenotypes (binding affinity and expression).
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵
www.science.org/doi/10.1126/...
Barred owlets of Ravenna Park
Barred owlets of Ravenna Park
This started in 2019 as daydreamy PhD student musings with Tatsuya Araki. We're as excited as ever about germinal centers as a platform for experimental evolution.
Many thanks to PIs @victora.bsky.social @matsen.bsky.social, co-1st authors Ashni Vora and Tatsuya, and many other key collaborators!
