PhD Candidate at Princeton University
Chemical and Biological Engineering Department
Biomolecular condensates, biophysics, and molecular simulations
Member of the Joseph Group (https://josephgroup.princeton.edu/)
Princeton '22-Present | Penn '18-'22
Nate
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Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]
Juan C. Landoni
Postdoctoral researcher @isaacsiuwong.bsky.social in the @hymanlab.bsky.social @mpi-cbg.de is 2026 Grass Fellow @grassfoundation.bsky.social @mblscience.bsky.social. 🎉 He will pursue his project “Dancing diatoms as a proto-neural model” at MBL for 14 weeks. www.mpi-cbg.de/news-outreac...
Here’s another condensate paper from the lab. We revisit biomolecular condensation—phase separation in protein suspensions—through the lens of critical phenomena. Kaarthik did excellent work characterizing mechanical properties and comparing their scaling behavior to the 3D Ising universality class.
Our second Cornell-era preprint is also out!
Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses.
Congrats, Kaarthik and the team!
www.biorxiv.org/content/10.6...
MPI-CBG postdoctoral researcher joins Marine Biological Laboratory, working in the Grass Laboratory for research project.
Max Planck Institute of Molecular Cell Biology and Genetics
Happy to share our first preprints from work originating at Cornell!
Takumi's paper describes how small molecules shift phase equilibria of condensates by focusing on the dilute-phase response. It shows how metabolites may tune stability and material properties.
www.biorxiv.org/content/10.6...
On the cover of #JCP, Pablo’s work on “Condensate Deborah Numbers”
pubs.aip.org/aip/jcp/arti...
New preprint! 🧪
What happens when phase separation couples to a nematic transition? 🫧
By combining experiment and theory 🔬, we find some pretty wild ternary phase diagrams! 🌈
Congrats on this milestone, Sully!
Check it out here. arxiv.org/abs/2605.26338
Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !
Laboratory of Soft and Living Materials @SoftLiv_Cornell
Laboratory of Soft and Living Materials @SoftLiv_Cornell
Laboratory of Soft and Living Materials @SoftLiv_Cornell
Jerelle Joseph
Takumi Matsuzawa
Gladfelter Lab
Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...
xavier salvatella
The druggability of intrinsically disordered regions.
The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
Our second Cornell-era preprint is also out!
Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses.
Congrats, Kaarthik and the team!
www.biorxiv.org/content/10.6...
Laboratory of Soft and Living Materials @SoftLiv_Cornell
Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...
