Bill James’ canonical example of signature signifance—performance at such a level that the sample size becomes irrelevant—is a hypothetical game in which Roger Clemens strikes out 15 with no walks.
Tim Marchman
Jacob Misiorowski!!
15 strikeouts
95 pitches
Shutout
That’s the most strikeouts in a Maddux (shutout on fewer than 100 pitches) since pitch counts have been tracked (1988)