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Excited to finally announce this work which has been in the pipeline for 5 years: Layers of Immunity. Faustine et al. made a set of immune mutants covering 4 major immune modules in #Drosophila, deleting melanization (ROS), phagocytosis, and both Toll & Imd NF-kB responses. What did we find? 1/n 🧵
The host innate immune response relies on the cooperation of multiple defense modules. In insects and other arthropods, which have only innate immune mechanisms, four main immune-specific modules cont...
www.biorxiv.org
Layers of immunity: Deconstructing the Drosophila effector response
Apr 1, 2025
Mark A. Hanson