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Fresh out of @ivaskalab.bsky.social on EPLINs' roles in integrin trafficking! Go have a look! 🎉
11mo
Michal Dibus
Very happy to share Niklas Jäntti's PhD work on EPLIN /LIMA1 isoforms (α/β) in breast cancer (spoiler: both have opposing roles in integrin traffic, cell migration & clinical outcome). This might explain why EPLIN sometimes has been reported as pro- and sometimes as anti-tumorigenic: bit.ly/3Iwjtau
11mo
Epithelial protein lost in neoplasm (EPLIN), an actin-binding protein, has been described as both a tumor promoter and tumor suppressor in different c…
bit.ly
EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration
Paulina Morlay