(4/5) Patterns emerged:
• Male reproductive cells → lower compensation
• Neural cells → higher compensation
• Other cells → normal compensation
Known regulators (RoX1 & RoX2) were involved—but couldn’t explain everything.
More biology to uncover 🔍
(3/5) What we found:
X-chromosome regulation spans a spectrum across cell types.
Some cells show lower activity, some are well balanced, and others show higher-than-expected activity.
Not a simple on/off switch.
(1/5) 🧬 Different organisms solve sex chromosome imbalance in different ways.
* In humans, females turn one X down
* In Drosophila, males turn their single X up.
Same goal: balanced gene expression.
But here’s the interesting question: does this balancing act work the same way in every cell type? 🤔
(2/5) One year ago, we published a microPublication:
“Cell-Type Specific Variation in X-Chromosome Dosage Compensation in Drosophila.”
A short, peer-reviewed study showing X-chromosome regulation isn’t one-size-fits-all. doi.org/10.17912/mic...
Using FlyCellAtlas+experiments, we reveal how organs scale via cell size/number diffs: bigger female flight muscles from more myoblasts, larger hearts from bigger cardiomyocytes, & fat body tweaks. Allometric Framework for sex diffs in growth!
#Drosophila #SSD #Allometry #Preprint
Excited to share our new preprint on bioRxiv: "Cell type specific allometry controls sex-differences in Drosophila body size"!
www.biorxiv.org/content/10.1...
Prototyping #rshiny apps to native #electron desktop apps:
shinyelectron::export() → #rshinylive conversion → .dmg → Native Mac app
Zero #rstats dependencies for end users! Early days but promising 👀
(5/5) Why revisit it now?
MicroPublications make focused results citable, open, and reusable.
If you work on dosage compensation, chromatin, genomics, or Drosophila, take a look 👇
🔗 doi.org/10.17912/mic...
#Drosophila #DosageCompensation #OpenScience
Species and sex-specific differences in organ size are fundamental features of animal biology, yet the mechanisms that drive these differences remain debated. Adult female Drosophila are larger than m...
