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Running code and kilometers in Cambridge. Spatial omics, neurodevelopment and more in Bayraktar lab, @sangerinstitute.bsky.social
Koen Rademaker
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Beyond excited to share my first work with Omer's group at Sanger! With amazing co-authors Alexander & Fani we are passionate about neurodevelopmental genetics and this work really showed us the power of uncovering new genetics with spatial transcriptomics! 🧵👇 Background / motivation / key results
The webinar series on spatial transcriptomics analysis is now open for registration! Join me on 18 March to learn how we at @bayraktarlab.bsky.social integrate single-cell and spatial transcriptomics to map the rules of neurological conditions.
7mo
Honoured to have received the Trainee Award for my talk together with @drjimmylee.bsky.social at the International Conference on Genomics and Systems Biology of Human Disease and Aging (@aegeanconf.bsky.social), with strong @bayraktarlab.bsky.social presence to showcase our spatial omics research.
Bayraktar, Bassett and Lotfollahi labs are studying how neurodegenerative diseases (ALS, PD, AZ) spatially organise 🧠🧬 Join us to generate & analyse wealths of Xenium data: - Tech specialist: sanger.wd103.myworkdayjobs.com/en-US/Wellco... - AI postdoc: sanger.wd103.myworkdayjobs.com/en-US/Wellco...
4mo
28d
11mo
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
I have an opening for a staff scientist or bioinformatician in my group at the Sanger Institute (closing date 24 March). Our current projects focus on disentangling rare and common variant contributions to rare neurodevelopmental conditions and to neurodevelopmental and perinatal traits. 1/2
I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism! We infer metabolic activity from single-cell & spatial transcriptomics 🧬 Read the pre-print here👇 📄 doi.org/10.1101/2025...