Nice demonstration by @maxgg.bsky.social et al that some, but not all, non tuberculous mycobacteria (NTM) intracellular growth in macrophages is pH sensitive
#TBSky #immunosky
onlinelibrary.wiley.com/doi/10.1111/...
Really important and relevant study in TB from @danbarberphd.bsky.social and colleagues. We need to re-think many assumptions. Nitric oxide production in mice has been a confounding factor. #tuberculosis
The time has come for big changes to research funding. New piece by RoRI’s Peter Kolarz on why incremental fixes may no longer be enough: journals.plos.org/plosbiology/...
The weekend is coming - use it to plan a trip to Belfast for the 2026 UK Cellular Microbiology Meeting!
Submit an abstract until 12th of May!
Great opportunity for early career researchers!
www.ukcellmicro.org
The 2026 UK Cellular Microbiology Network Meeting is approaching fast!
Submit an abstract until May, 12th and join us June, 22nd/23rd in Belfast!
Exiting keynote speakers and opportunities for early career researchers from the UK, Ireland and beyond to share their work.
www.ukcellmicro.org
Very excited this work by Victor and Jakson @crick.ac.uk is out!! started many years ago with @jvaubourgeix.bsky.social They generated Mtb-Timer, a fluorescent reporter in Mtb as a proxy for Mtb replication and measure antibiotic responses Mtbhttps://journals.asm.org/doi/10.1128/msystems.01796-25
Was just asked to spread the word about this position.
Structural biology and Chemical Biology positions in Barcelona, one of the great cities of the world!
www.irbbarcelona.org/sites/defaul...
Gabriele Pollara
In this systematic review & meta-analysis, Mortazavi & colleagues (@petermacp.bsky.social) investigate urban vs rural differences in #TB prevalence between 2000 and 2024 in 26 low- and middle-income countries, finding that TB epidemics have become increasingly urbanized 🧪 #MedSky
plos.io/3O79BqY
Max Gutierrez
We are looking for an experienced light microscopy specialist, motivated to support our users in the Advanced Light Microscopy Facility at EMBL Heidelberg.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j... -closing date 11 May 2026 @eurobioimaging.bsky.social @globalbioimaging.bsky.social
Research on Research Institute (RoRI)
One week left to apply. Help us find new antimicrobials and understand the inner workings of bacteria – as a technical assistant in the Machine Biophotonics and Nanoscale Bacteriology labs at the Rudolf-Virchow-Zentrum, University of Würzburg – See details below (in German). Please spread the word.
Tuberculosis treatment is challenging in part because Mycobacterium tuberculosis (Mtb) populations are phenotypically heterogeneous. Within the same infection, bacterial cells can exist in different physiological states, from actively replicating to slow-growing or non-replicating forms. To better study these processes, we developed and validated Mtb-Timer, a fluorescent reporter that enables visualization of bacterial growth dynamics. The system is based on a fluorescent protein that changes color over time: newly synthesized protein emits green fluorescence (GFP) and gradually shifts to red (DsRed) as it matures. The green-to-red fluorescence ratio, therefore, reflects bacterial replication activity. Using microscopy and flow cytometry in both in vitro cultures and infected macrophages (in cellulo), Mtb-Timer enables the quantification of distinct bacterial subpopulations and the real-time monitoring of the green-to-red fluorescence ratio and bacterial burden during treatment with first-line antibiotics.
Different nontuberculous mycobacteria (NTM) species display unique replication profiles in acidic pH in vitro which correlates to their replication within human macrophages. Inhibition of the acidic ....
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
In a systematic review and meta-analysis, Seyed Alireza Mortazavi and colleagues investigate urban versus rural differences in adult pulmonary tuberculosis prevalence between 2000 and 2024 in 26 low- ...
plos.io
Registration and abstract submission for the 2026 UK CellularMicrobiologyNetwork Meeting are now open!
Exiting keynote speakers and opportunity for researchers from the UK, Ireland and beyond to share their work on host-pathogen interactions.
June 22nd/23rd @WWIEM in Belfast.
www.ukcellmicro.org
Nature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...
