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Beautiful work by @kkjimbsky.bsky.social in collaboration with @nvastenhouw.bsky.social @pengellab.bsky.social where we used CRISPRi-seq in a zebrafish meningitis model of pneumococcal infection coupled with metabolomics. #MicroSky www.biorxiv.org/content/10.1...
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In vivo genome-wide CRISPRi-Seq in Streptococcus pneumoniae reveals host-adaptive pathways essential for meningitis and identifies new therapeutic targets
Streptococcus pneumoniae is an important human pathogen that causes invasive diseases and remains the leading cause of bacterial meningitis. However, the bacterial determinants required for survival w...
www.biorxiv.org
Jan-Willem Veening