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New preprint led by Vik Minhas that shows that only a small subset of epithelial cells actually respond to pneumococcal infection and activate innate immune genes. Great collaboration with @bartdeplancke.bsky.social @roi1avraham.bsky.social www.biorxiv.org/content/10.6...
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Streptococcus pneumoniae colonises the nasopharynx asymptomatically yet causes life-threatening invasive disease. How it navigates early epithelial immune surveillance to cause disease remains unclear...
www.biorxiv.org
Epithelial innate immune sensing of pneumococci is inherently restricted to a small cellular minority across species and infection niches
Jan-Willem Veening