We identify novel catalytically impaired PARP1 mutants and show that the toxicity of some variants in cells can be rescued by the PARP inhibitor saruparib. Thus, in specific contexts, saruparib plays a pro-survival role rather than a cytotoxic one.
www.cell.com/cell-reports...
Interesting paper on PARP4 and the phosphorylation, sumoylation, and ADP-ribosylation cascade in apoptosis regulation, with a small contribution from our team.
www.science.org/doi/10.1126/...
We show that the E3 ubiquitin ligase DTX2 creates a dual hybrid ADP-ribosyl-ubiquitin mark (ADPr-Ub) at DNA damage sites, driving the recruitment of RNF114, RNF138, and RNF166 proteins independently of HPF1.
journals.plos.org/plosbiology/...
Assembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts www.nature.com/articles/s41... @natcomms.nature.com
#RIP Pierre Chambon (1931-2026) via @alainberetz.bsky.social
one of the last giants in biology: PARP, nuclear receptors, RNA Pol II, nucleosome, promoters, split genes
