Senior Scientist at ETH Zurich. Developing GCE tools to dissect complex biological Systems.
Max Fottner
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
Super proud of this story! ☺️ Huge thanks to @taruniype.bsky.social for the amazing work - and to @klanglab.bsky.social for the constant support! The first time we saw that phenomenon actually goes all the way back to my Master’s thesis in 2016 🫣 Every now and then, persistence pays off 🤞
ChemBioHub - Huber Lab
DeBerardinis Lab at UT Southwestern Medical Center
Pedro Beltrao
Rune Busk Damgaard
Peptide passports: Programmable import fuels novel protein building blocks
Max Fottner
Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go!
go.bsky.app/DDpDuvo
Researchers from ETH Zurich have succeeded in introducing large quantities of unnatural #AminoAcids into #Bacteria, enabling the creation of innovative and highly efficient designer proteins. These can be used as more efficient catalysts or more effective #Drugs.
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
Proteins with noncanonical amino acids can serve as precision tools and therapeutics, but their creation is often inefficient. In a recent Nature publication, Iype et al. engineered bacteria to ferry designer amino acids as peptide cargos, overcoming a major uptake bottleneck and enabling robust, scalable incorporation under routine culture conditions.
Researchers from ETH Zurich have succeeded in introducing large quantities of unnatural amino acids into bacteria, enabling the creation of innovative and highly efficient designer proteins. These can...
🚨Our paper is out! 🥳
Hijacking a bacterial ABC transporter for efficient genetic code expansion.
Many congrats to everyone involved - a multi-year effort led by @taruniype.bsky.social @maxfottner.bsky.social
www.nature.com/articles/s41...
it all started years ago with a failed experiment
🧵👇 1/9
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel func...
