Genomes? Pah, who needs them... let's delete them!
Rory Maizels
New š§¬āļø pre-print! We show that paired prime editing can efficiently generate large deletions ā even >1 Mb ā with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
š biorxiv.org/content/10.1...
A short thread (by Juliane Weller)š
biorxiv.org
Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...
