Excited to share our new preprint!
Using deep mutational scanning and multivalent engineering, we developed our SARS-CoV-2 spike-targeting macrocyclic peptide into a potent inhibitor that blocks infection in HAE cultures and protects hamsters after intranasal dosing.
chemrxiv.org/doi/full/10....
The risk of zoonotic spillover of coronaviruses poses a constant threat to humanity, as recently exemplified by SARS‑CoV-2. During the pandemic, the rapid emergence of immune escape mutations led to a loss of efficacy of both therapeutic and humoral anti‑...
