#RobSelects paper of the week #NatureChemistry: Switchable copper-catalyzed N-alpha or N-beta arylation of 3-substituted pyrazoles via ligand choice #catalysis https://doi.org/10.1038/s41557-026-02148-z
N-aryl pyrazole is a prevalent motif among pharmaceuticals across various therapeutic areas but can be challenging to synthesize due to the high similarity of the two nitrogen atoms. Now it has been shown that the use of copper catalysis and arynes provides a switchable protocol to access both regioisomers.
