Very excited to share MIMIC: check it out! An amazing team effort!
*postdoc job alert* Are you interested in theory and experiment for time-resolved cryo-EM? If so see below 👇 a collaboration between the Crick and the Flatiron Institutes 💻🔬
Excited so share our theoretical work on cryo-EM vitrification and recovering ensemble distributions!!
#BPS2026 The T&C subgroup is hosting a fun event on Saturday evening, Feb 21st 🎉 Open bar for 2 hours + food! Tickets are selling fast, so sign up soon: www.biophysics.org/2026meeting/...
Check out our Flatiron team @BPS2026!
How can we extract unbiased transition rates from ligand-unbinding Random Acceleration MD (RAMD) simulations? Our new paper lays out the theoretical framework behind RAMD. Take a look! doi.org/10.1063/5.03... @benoitroux.bsky.social @yiweiding.bsky.social & Alessia Ghidini #MD #drugdiscovery
Celebrating #BiophysicsWeek T&C partnered with Phase Space Invaders podcast: Robert Best @sonyahanson.bsky.social @xuhuihuangchem.bsky.social and host @milosz-wieczor.bsky.social Episode 32: Driving the Future of Biophysics: What’s Next in Theory and Computation?
www.buzzsprout.com/2313153/epis...
Go use cryojax ! It's awesome! I can't wait to see what people do with it.
With the convergence of data, computing power, and new methods, computational biology is at its most exciting moment. At PSI, we're asking the leading researchers in the field to discover where we're ...
@flatironinstitute.org senior research scientist Pilar Cossio builds crucial tools to reveal how environmental changes alter the behavior of RNA: https://bit.ly/48rCAg2 #science #biology
#FlatironCCM researchers have developed a new tool called ROCKET that extends the capabilities of AlphaFold by directly learning from raw experimental data: https://bit.ly/4dUTZkG #science #math
Miro Astore
Flatiron Institute researcher Pilar Cossio builds tools to analyze experimental measurements and reveal how environmental changes alter the behavior of RNA molecules.
The dissociation of a ligand bound to a receptor is a rare event occurring on a timescale that is far longer than can be afforded by standard simulation methodo
We just preprinted one of my favorite studies @FlatironInst
. I was lucky to be part of an amazing team studying the effects of rapid cooling to preserve samples in cryoEM. Read on to learn about the limits of cryoEM for biophysics and how to overcome them www.biorxiv.org/content/10.6...
Introducing ROCKET: An Upgrade to AlphaFold That Learns From Raw Experimental Data on Simons Foundation
Introducing MIMIC: a new foundation model trained natively across DNA, RNA and proteins. MIMIC is multimodal and generative: it can use structure, regulation, evolution, and experimental context to infer missing biology or design new sequences. 🧵⬇️
Excited to announce this postdoc position at the intersection of experiment and computation for time-resolved cryo-EM! It's a collaboration between the Enchev group at the Crick and myself and @pilarcossio.bsky.social at the Flatiron Institute! Plz share.
crick.wd3.myworkdayjobs.com/External/job...
A great start to the Biophysical Society Annual Meeting in San Francisco! Check out the various projects being presented on work from Flatiron Institute people! #bps2026
We developed a simple theory and showed that Random Acceleration Molecular Dynamics (RAMD) is consistent with a Smoluchowski equation with an effective temperature and diffusion coefficient that depend quadratically on the magnitude of the random force.
pubs.aip.org/aip/jcp/arti...
Sonya
Sonya
Samuel Sledzieski
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Michael J. O'Brien et al.: CryoJAX: a cryo-electron microscopy image-simulation library in JAX #CryoEM #ImageSimulation #AutomaticDifferentiation @harvard@unewhaven@Cornell...#IUCr https://journals.iucr.org/paper?S2059798326000550
Structural Biology
Video
The dissociation of a ligand bound to a receptor is a rare event occurring on a timescale that is far longer than can be afforded by standard simulation methodo
Salary for this Role: From £53,025 per annum plus benefits, subject to skills and experience Job Title: Senior Data Scientist Reports to: Radoslav Enchev Closing Date: 06/May/2026 23.59 GMT Job Descri...
The authors have developed cryoJAX, a cryo-EM image-simulation library for developing data-analysis techniques across cryo-EM modalities. CryoJAX is built on JAX, an emerging scientific computing framework in Python well suited for cryo-EM data analysis.
