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Do you work in 💫human genetics💫? Have you ever worried about what’s inside your gene annotation GTF⁉️ WELL, YOU SHOULD! 😱 Especially when studying a genetically diverse 🌍 cohort! 🔴We discover that gene annotations are European-biased 👉 impacting downstream analyses! Don't miss this thread🧵⬇️ 1/13
Mar 20, 2025
Accurate gene annotations are fundamental for interpreting genetic variation, cellular function, and disease mechanisms. However, current human gene annotations are largely derived from transcriptomic...
www.biorxiv.org
Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation
Melé Lab