Neuro postdoc at UCC 🇮🇪 PhD at MPI-NAT, 🇩🇪 | Alzheimer's x glia x sex differences x gut microbiome 🔬🧠 | (he/they) 🏳️🌈
Andrew Octavian Sasmita
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Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice
www.nature.com/articles/s41...
Microglial CD31 is increased in Alzheimer’s disease and limits amyloid clearance. Reducing CD31 enhances Aβ degradation, alleviates pathology, and improves cognitive function in mouse models.
Now online! Nuclear proteome reveals microtubule-associated protein regulating fate and disease
Andrew Octavian Sasmita
Female Clinical Resilience Despite Pathologic Risk in Alzheimer's Disease
jamanetwork.com/journals/jam...
Dysregulated oligodendrocyte and myelin dynamics as an early pathological feature of neuropil degeneration in Alzheimer’s disease: an ultrastructural study
link.springer.com/article/10.1...
Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice www.nature.com/articles/s41...
Early Myelination Supports the Establishment of Consistent Handedness
onlinelibrary.wiley.com/doi/10.1002/...
Astrocytes reduce microglial activation and enhance adult hippocampal neurogenesis in acute inflammation
www.sciencedirect.com/science/arti...
Actin disassembly triggers CNS myelin compaction and wrapping https://www.biorxiv.org/content/10.64898/2026.05.14.722739v1
Amyloid beta exacerbates Tau-seeded pathology and drives tangle formation in human neuronal xenografts #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-9942622/latest
Cell - a Cell Press journal
Andrew Octavian Sasmita
Andrew Octavian Sasmita
Like macrophages in general, Lipid-associated “foamy” 🚿macrophages come in different flavors. Here a new story on these big beauties in #multipleSclerosis
Foamy microglia link oxylipins to disease progression in multiple sclerosis | @natneuro.nature.com
www.nature.com/articles/s41...
