Full paper and research summary now out in Science: www.science.org/doi/10.1126/.... Also, an excellent summary of our work in the Times: www.thetimes.com/uk/science/a...
Great thread by lead author @edogia.bsky.social on our recent Science paper: bsky.app/profile/edog...
Great summaries of our paper www.science.org/doi/10.1126/... in Science: www.science.org/doi/epdf/10.... and New Scientist: www.newscientist.com/article/2515... and in the Science museum blog: blog.sciencemuseum.org.uk/in-the-begin...
Have a look at the Insight on Research story on our Science paper www.science.org/doi/10.1126/... on the @mrclmb.bsky.social website: mrclmb.ac.uk/news-events/... including a great little animation from LMB VisLab.
Phil Holliger
Phil Holliger
Led by Edoardo Gianni, Philipp Holliger’s group in the LMB’s PNAC Division have identified a small self-replicating catalytic RNA (ribozyme), providing new ...
mrclmb.ac.uk
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
Have a look at our latest results on #CDK regulation, just posted as a pre-print! This study was spearheaded by PhD student Amy McGeoch. Amy has determined the #cryoEM structure of the CDK11-cyclin L-SAP30B complex, an important regulator of #spliceosome activation.
www.biorxiv.org/content/10.6...
Phil Holliger
Phil Holliger
🧬Want to synthesise kilobase-scale DNA? We got you covered!🥳 In latest from the lab we explore the "doodling" capabilities of DNA polymerases and ways to guide the sequences produced. Loads of data + beautiful AFM of the molecules themselves. #synbio ... doi.org/10.1038/s414...
Proud to share the yeast telomerase structure, led by the talented @hongmiaohu.bsky.social in collaboration with the Wellinger and Chartrand labs. Discovered 37 years ago and took us nearly 7 years but totally worth the wait 😍.
www.science.org/doi/10.1126/...
www.youtube.com/watch?v=gFE4...
I am so grateful to the Blavatnik Family Foundation and the New York Academy of Sciences for this honor. Can’t wait to be back to the lab and celebrate with lab members on this special recognition of their hard work.
Grateful to the unique environment and long-term support of the MRC-LMB (@mrclmb.bsky.social) & Holliger lab, and a big thank you to the rest of the team: Sam Kwok, @chrisjwan.bsky.social, Kevin Goeij, @bryceclifton.bsky.social, @escolizzi.bsky.social, James Attwater, @philholliger.bsky.social.
12/n
The LMB is thrilled to announce the appointment of @ivanabukvin.bsky.social as a Group Leader in the PNAC Division.
Beginning in January 2027, Ivana’s group will investigate co-translational folding and misfolding of proteins.
Read more: mrclmb.ac.uk/news-events/...
YouTube video by MRC Laboratory of Molecular Biology
www.youtube.com
Thomas Gorochowski
Kelly Nguyen
Kelly Nguyen
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
www.science.org
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
Led by Investigator Scientist @hongmiaohu.bsky.social, @kellythd-nguyen.bsky.social’s group in the LMB’s Structural Studies Division have produced the first ever structure of telomerase from yeast.
Read more here: mrclmb.ac.uk/news-events/...
#LMBResearch #cryoEM 🧪
