Host-pathogen biomechanics || Researching how shear stresses impact infections of endothelial cells || PhD Candidate @bastounislab at University of Tübingen
Erva Keskin
Bastounis lab had a great time at @cellmech2025.bsky.social — such an engaging and well-organized #Mechanobiology conference in Leuven 🙌 Thanks to everyone for the inspiring exchanges! And big congrats to our lab member @hundsdorfer.bsky.social for winning the Best PhD Student Poster Prize 🎉
Check out our newest publication in @cp-cellreports.bsky.social
#Mechanobiology #HostPathogen #Listeria
Erva Keskin
Erva Keskin
Erva Keskin
Listeria-infected macrophages promote biomechanical alterations in endothelial cell monolayers for transmigration
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers and spread systemically. Muenkel et al. show that exposure to infected macrophages weakens contractile forces within the endothelial monolayer and promotes macrophage transmigration. This response is driven by direct cell-cell interactions, with cytokines exerting only minor and transient effects.
Very excited for the upcoming "Mechanobiology of Infection" meeting we are organizing with Alexandre Persat and Daria Bonazzi. Thanks to @biophysicalsoc.bsky.social Society for their support - looking forward to it! Abstract submission and registration here: www.biophysics.org/meetings-eve...
I'm excited to share our paper on how infected #macrophages promote #biomechanical alterations in #endothelia to transmigrate, published in @cp-cellreports.bsky.social! Thanks to all contributors, @sergemostowylab.bsky.social and @cmfi.bsky.social for the support. Here: www.cell.com/cell-reports...
www.cell.com
Intracellular pathogens like Listeria exploit macrophages to cross endothelial barriers
and spread systemically. Muenkel et al. show that exposure to infected macrophages
weakens contractile forces wi...
