RCT 7 vs 14 days of treatment for P. aeruginosa BSI.
Updated trial progress and #FOAMed on P. aeruginosa.
#AMSSky #IDSky #PsWatch
Powered by @guiaprioam.bsky.social
📚 Full protocol: https://shorturl.at/xN0wj
🌐 https://clinicaltrials.gov/study/NCT05210439
SHORTEN-2 trial
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👏 Investigadoras @ibis-investigacion.bsky.social desarrollan una prueba rápida para detectar una bacteria resistente en sangre.
🔍La nueva herramienta permite identificar en pocas horas la bacteria Pseudomonas aeruginosa y uno de sus factores de virulencia más agresivos.
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Can we use short treatments for bacteremia in #SOT?
This metaanalysis of observational data + SOT randomized in prior trials suggests the efficacy of short courses.
We’ve got the rationale to stop excluding SOT from duration trials!
onlinelibrary.wiley.com/doi/10.1111/... #IDSky #AMSsky #TxID
Amazing 😍
🔥SHORTEN 2 RCT
A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky
@shorten2trial.bsky.social
SHORTEN2 results have been presented at #CongresoSEIMC2026!
7-day treatments were shown superior to 14-day in reducing antibiotic exposure and adverse events while maintaining efficacy.
Fantastic work by >100 researchers across 37 Spanish hospitals! #TeamPride #IDsky #AMSsky @seimc.bsky.social
We’re happy to share that results of the @shorten2trial.bsky.social will be presented at the #XXIXCongresoSEIMC!
📆 Friday, May 29 - 14:25h
📍Room 0D
📻 Stay tuned! #AMSsky #IDSky @absteward.bsky.social @idstewardship.bsky.social @bradspellberg.bsky.social @drtoddlee.bsky.social @esgap.bsky.social
We’re happy to share that results of the @shorten2trial.bsky.social will be presented at the #XXIXCongresoSEIMC!
📆 Friday, May 29 - 14:25h
📍Room 0D
📻 Stay tuned! #AMSsky #IDSky @absteward.bsky.social @idstewardship.bsky.social @bradspellberg.bsky.social @drtoddlee.bsky.social @esgap.bsky.social
SHORTEN-2 trial
🔥 💥Late-Breakers |COBRA RCT
1-day of antibiotic treatment after adequate endoscopic biliary drainage is non-inferior to 4-7 days in adults with acute cholangitis.
💡 Shorter is better+source control
Practice-changing? #ESCMIDGlobal2026 #idsky
For years, the need for longer durations in immunocompromised patients was treated as the exception to every shorter-duration bacteremia discussion.
BALANCE may have finally put that belief to rest.
Dogma continues to lose ground. #idsky
What's in a name?
Pseudomonas aeruginosa—from Sédillot’s blue-green wound dressings and grapes like odor (1850), to Gessard’s isolation (1882), to Migula’s formal naming of the genus (1900).
A pathogen that made its name unforgettable recognizable #IDsky
Universidad de Sevilla
ESCMID 2026 highlights
COBRA Trial – One day is enough
Dutch RCT: 1 day of antibiotics after ERCP drainage for cholangitis was non‑inferior to 4–7 days.
Bottom line: Antibiotic durations can safely be much shorter once source control is achieved.
#IDSky
clarityinitiative.org/escmid-2026-...
Antibiotic Steward 🅱️C🆔🅿️🌟
SHORTEN-2 trial
SHORTEN-2 trial
SHORTEN-2 trial
Antibiotic Steward 🅱️C🆔🅿️🌟
Clinical Literature Appraisal and Research education in InfecTious diseases
In this meta-analysis of seven studies involving 249 solid organ transplant (SOT) recipients with Gram-negative bloodstream infections, no statistically significant differences in mortality or clinic....
🆕🔥🟢Post hoc subgroup analysis of the BALANCE RCT 7 Vs 14d duration of antibiotic therapy for bacteremia in immune compromised hosts
1037 immune compromised patients #idsky
www.clinicalmicrobiologyandinfection.org/article/S119...
