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We study lamins and nuclear mechanobiology. Meinig School of Biomedical Engineering. Weill Institute for Cell and Molecular Biology. Cornell University. https://lammerding.wicmb.cornell.edu/

Jan Lammerding - Lab

Attending #EESMechanobiology ? If so, be sure to find and chat with @djdavid.bsky.social (Daryl), one of our senior scientific editors. He'll be on site on Tuesday and Wednesday.

Two recent new publications from our laboratory, led by the amazing Jacob Odell and Maggie Elpers, respectively, shed new insights into the role of nuclear #lamins and nuclear #mechanobiology in two different contexts.

First long term confocal imaging #Zeiss from the lab. Adipose-derived stem cells expressing LifeAct.

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Jan Lammerding - Lab

Nature Cell Biology

This increase in nuclear stiffness was due to compaction of chromatin associated with polarization into M1-like macrophages and affected the ability of the M1-like macrophages to migrate through confined spaces. Stay tuned for further updates and insights!

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Given the important function of LBR in chromatin organization, these findings point to a competitive model between A-type lamins, B-type lamins, and LBR at the nuclear envelope that could play key roles during development and disease.

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In the second story, led by Maggie and published in npj Biological Physics and Mechanics (rdcu.be/fl0V8), we found that polarization of bone marrow derived macrophages results in increased nuclear stiffness, despite a decrease in lamin A/C levels.

Jan Lammerding - Lab

Another attempt to include some figures from the two papers, which were somehow reduced to black boxes in the original post.

Interested in #Mechanobiology? Join us for the Mechanobiology Symposium, hosted by the new Cornell Mechanobiology Hub @weillinstitute.bsky.social in Ithaca, NY, this summer. More information at mechanobiology.wicmb.cornell.edu/events-progr... Deadline for abstract submission is April 15, 2026

In the first story, published in Nucleus (www.tandfonline.com/doi/10.1080/...), we demonstrate that lamin A can result in displacement of LBR from the nuclear envelope to the endoplasmic reticulum (ER).

Great start to the Cornell Mechanobiology Hub Symposium hosted by the @weillinstitute.bsky.social, with keynote speaker Amy Shyer and over 180 participants from more than 15 institutions. #Mechanobiology thrives in Ithaca and the region, including Syracuse, Rochester, Buffalo, and Binghamton.

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Jan Lammerding - Lab

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Jan Lammerding - Lab

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Enroute to #EESMechanobiology! proud to represent both @natcellbio.nature.com as senior editor and npj Biological Physics & Mechanics as advisory editor. Let's discuss your interesting work, science publishing, & more! Find me around &at the #MeetTheEditor lunch On Wed. Note, I'm only here Tues+Wed

Daryl Jason Verzosa David