In previous work published in @nataging.nature.com, we showed that lysosomes transform into tubular networks upon food limitation; this morphological transformation of lysosomes promotes faster autophagic cargo turnover and is required for the beneficial effects of dietary restriction.
The authors report that a change to lysosome morphology, from vesicular to tubular form, supports lifespan extension upon dietary restriction and promotes heightened autophagy and healthy aging when s...
