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同義置換でもタンパク質折りたたみに影響 タンパク質の折りたたみエラーを検知するアッセイ系を用い、アミノ酸に変化がない同義置換でもタンパク質折りたたみに影響することを報告。レアコドンはむしろ折りたたみ効率を向上させるらしい。N末端領域や二次構造の境界が特に大事とか www.cell.com/cell-reports...
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Otsuka et al. performed a systematic in vivo scan of synonymous substitutions and found single codon changes that alter folding efficiency in a native E. coli protein. Rare codons help prevent…
Effects of single synonymous substitutions on fold efficiency demonstrate the influence of rare codons and protein structure
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