looking at replication origin firing in human cells
Views are my own, this is a personal account
https://moiseevalab.com/
DNA replication, genome stability, DNA polymerase epsilon, cancer research
Tatiana Moiseeva
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TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data.
@sholtodavid.bsky.social @johanduchene.bsky.social
reeserichardson.blog/2026/05/28/h...
So honored that the graduate students of the Oncology Graduate Program voted me the outstanding faculty member! I feel very grateful, and enjoyed every minute of teaching, supervising and mentoring them!
My cell has (is?) a foot!
This cat is raising money for cancer research! Please consider donating if you want to support his human's work:)
haku.ly/c16963dbc3
First NIH grant for the lab!! Very nice way to start the week :)
Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated!
www.biorxiv.org/content/10.6...
Students need to remember that Inigo Montoya method for emails and greetings:
"Hello, my name is Inigo Montoya. You killed my father. Prepare to die.”
Polite Greeting
Name
Relevant Personal Link
Manage Expectations
Keep it BRIEF.
New preprint🎉
Happy to share our collaborative manuscript, where we provide in vivo and genome-wide evidence linking MCM2-7 helicase activation, DNA extrusion to initial origin melting, thereby adding a new mechanistic layer to how eukaryotic DNA replication is initiated.
👉 doi.org/10.64898/202...
Excited to share our latest paper! We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. @cp-cell.bsky.social (1/7)
www.cell.com/cell/fulltex...
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
Read our latest work - a comprehensive review on how DNA secondary structures affect replication.
Very proud of Adi, Maria and Billie for their monumental effort. They've covered a large body of literature while proposing updated models.
Open Access in DNA Repair:
doi.org/10.1016/j.dn...
doi.org
Tatiana Moiseeva
Tatiana Moiseeva
Tatiana Moiseeva
Tatiana Moiseeva
Reese Richardson
Tatiana Moiseeva
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…
am i the only 1 who wishes ppl would remind me that we've interacted before if it's plausible i've forgotten? I've had like 3-4 emails that seems like 'cold emails' ab research opportunities but then it turns out we've exchanged emails in the past & it's awkward to not have realized this? just me?
