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Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes. www.nature.com/articles/s41...
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PROTACs induce degradation by bridging a target protein and E3 ubiquitin ligase. Here, authors show that protein interface frustration correlates with cooperativity, offering a structural metric to prioritize PROTAC candidates prior to synthesis.
www.nature.com
Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes - Nature Communications
Geming Lu