Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
Rasmus Hartmann-Petersen
BAG6 and RNF126 are broadly involved in protein quality control of non-native missense protein variants https://www.biorxiv.org/content/10.64898/2026.02.04.703735v1
