New preprint!
Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability.
We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
Rasmus Hartmann-Petersen
Mapping the GCK-GKRP interaction landscape using deep mutational scanning by reverse two-hybrid screening https://www.biorxiv.org/content/10.64898/2026.01.15.699699v1
