Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
š doi.org/10.1093/molbev/msaf300
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Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
