My paper on bacterial type ii topoisomerase cleavage patterns just came out today in @narjournal.bsky.social! In it, my coauthors and I show that these essential enzymes have species-specific cleavage preferences, which could be important for their role as antibacterial drug targets 🧪
Abstract. The type II topoisomerases, gyrase and topoisomerase IV, are ubiquitous enzymes in bacteria that help regulate DNA topology and are the molecular
