Immune responses in mice against H5N1 LAIV backbone. F mice = 🔺 total IgG, IgG against NA (vs HA). IgG x recognition aginst H1N1 also mostly in F. FcR-mediated non-neutralizing response against HA and NA robust in both sexes.
👉 www.biorxiv.org/content/10.6...
Michelle Wille
Using a commercially available H5 serology assay, 7.4% (n=5/68) anti-H5 seroreactivity rate detected in hunters in Northern Manitoba, Canada. Knowledge and concerns about H5N1 among study participants was low
👉 www.medrxiv.org/content/10.6...
California, 2024/25. 19 HPAI infected cats, 139 human contacts. 1 asymptomatic vet had antibodies agsinst H5 after occupational exposure to an H5N1-infected cat.
👉 www.cdc.gov/mmwr/volumes...
What a resource - high-resolution, multilayered spatiotemporal representation of the contiguous U.S., integrating livestock populations, processing centers, wild bird abundances, and human demographics. Ueeful for HPAI modelling!
👉 www.pnas.org/doi/abs/10.1...
Assessment of H5 antibodies in humans, 1928-1999. Born before 1957 = highest pre-existing serum antibodies to group 1 including H5 + group 1 HA stem antigen. Pre-existing nasal IgG + IgA titres to H5 greater in individuals born prior to 1957.
👉 www.biorxiv.org/content/10.6...
In 2024, Finland global forerunner to offer H5 vaccine to occupational risk groups. Only 8.6% got 1st dose, 7.5% both doses. Low rates = logistical failures, divergent risk perceptions, political distrust.
👉 doi.org/10.1016/j.va...
Human case of H5 in Canada had mixture of 226Q/H in the HA RBS. Here, Q226H mutation enables binding to human-type a2-6 sialic acid receptors, but also that confirmational change of a2,6 glycan.
👉 www.biorxiv.org/content/10.6...
Human in New York, pre-existing immunity at population level to H9N2, but with lower magnitude than those against seasonal H3. Many had N2-binding and NI antibodies.
👉 www.eurosurveillance.org/content/10.2...
H7N2 + H7N4 from migratory birds, 2017-24, E China: infect domestic ducks and chickens and replicate efficiently in mice without prior adaptation. - PB2-E627K important.
👉 www.sciencedirect.com/science/arti...
Intramammary inoculation of B3.13, with 10 TCID50 = robust infection + shedding of high-titer virus in milk. BUT does not readily transmit via contaminated milking equipment and close contact with infected animals. Rep + oral unlikely to establish infection.
👉 link.springer.com/article/10.1...
