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šŸ§¬ How does SLX4 switch between DNA binding and MUS81 interaction? Scaglione & Gaillard identify CDK1 phosphorylation as a molecular switch that regulates distinct functions of the SLX4 SAP domain during genome maintenance. šŸ”— crcm-marseille.fr/en/gaillard-... #CancerResearch #DNARepair
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Scaglione and Gaillard show that the SLX4 SAP domain selectively binds four-way branched DNA structures. Their findings identify CDK1 phosphorylation as a molecular switch that inhibits DNA binding wh...
CDK1 phosphorylation switches SLX4 SAP from DNA binding to MUS81 binding
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