This month #JEMLegacy is going back to 1987 when Marc Jenkins and Ronald Schwartz first described that TCR engagement (signal 1) alone induces T cell unresponsiveness and anergy, setting the stage for the understanding of T cell costimulation 🧪 Take a look here 👉 tinyurl.com/4sebepmr
We investigated the antigen specificity and presentation requirements for inactivation of T lymphocytes in vitro and in vivo. In vitro studies revealed tha
