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See this detailed thread on our paper. In sum, evidence shows fluoxetine has no meaningful effect. Earlier studies influenced by recency bias. But it is still recommended in clinical guidelines
4mo
Joanna Moncrieff
Paper now published in the Journal of Clinical Epidemiology. Longer thread below! www.jclinepi.com/article/S089... @markhoro.bsky.social @joannamoncrieff.bsky.social @richlyus.bsky.social @floriannaudet.bsky.social
7mo
Fluoxetine is among the most used antidepressants for children and adolescents and frequently recommended as first-line pharmacological treatment for pediatric depression. However, in contrast to earl...
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The loss of efficacy of fluoxetine in pediatric depression: explanations, lack of acknowledgment, and implications for other treatments
Martin Plöderl
1/32 Fluoxetine's loss of efficacy for the treatment of pediatric depression. 🚨 New paper and pre-print alert 🚨 With great colleagues @floriannaudet.bsky.social @richlyus.bsky.social @markhoro.bsky.social @joannamoncrieff.bsky.social and Gert van Valkenhoef A longer 🧵
9mo
Martin Plöderl