Super excited to tell you about our preprint on Neighborhood Nonnegative Matrix Factorization (NNMF) for spatially-aware dimension reduction in spatial transcriptomics, led by Ragnhild Laursen in collaboration with Karin Pelka @pelkalab.bsky.social and her lab!
www.biorxiv.org/content/10.1...
Tissues consist of multi-cellular neighborhoods in which different cell types express correlated gene programs due to shared signaling environments. Methods for identifying these spatial neighborhoods...
