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Happy to share this paper from our lab, with @jlmcfalinefigueroa.bsky.social’s group, out in its final form at Science Advances! Big congrats to lead authors Anne van Vlimmeren and Ross Giglio! www.science.org/doi/10.1126/...
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www.science.org
RNA sequencing of cells expressing SHP2 disease mutants shows how changes to enzyme structure cause different cellular outcomes.
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants
Neel Shah
Check out our latest preprint, from Anne van Vlimmeren in my group and Ross Giglio in @jlmcfalinefigueroa.bsky.social's lab. We used single-cell transcriptomics, biochemistry, and structural analysis, to reveal how mechanistically distinct SHP2 disease mutations yield different cellular states.
11mo
Neel Shah
Multiplexed single-cell transcriptomics reveals diverse phenotypic outcomes for pathogenic SHP2 variants https://www.biorxiv.org/content/10.1101/2025.06.30.662374v1