🚨 NEW REVIEW⚕️ 🩺
Tao et al. summarize evidence linking HIV-1 Env sequence characteristics to reduced bnAb susceptibility, including in vivo selection data in animal models and human studies, and in vitro selection and susceptibility data.
Tao et al. review clinical and experimental data linking HIV-1 Env sequence features to reduced broadly neutralizing Ab susceptibility. While genotypic analysis identifies many predictors of reduced susceptibility, larger datasets and more advanced models will be required before genetic methods can reliably predict susceptibility in clinical settings.
