Big thank you to @calumgabbutt.bsky.social @dmallo-phylo.bsky.social @heathergrant.bsky.social @trevorgraham.bsky.social @cmaley.bsky.social and Darryl Shibata!
Postdoctoral researcher at the Institute of Cancer Research, London. Bioinformatician 🖥️🧬 Cancer genomics, cancer evolution and precision medicine
Ben O'Leary & I are looking for a #postdoc to join us in @cec-icr.bsky.social to work on collaborative @cancerresearchuk.org RadNet project about the interrelationship between genome & epigenome instability and radiotherapy response.
Details & apply here: jobs.icr.ac.uk/vacancies/11...
@icr.ac.uk
We then thought what else we could learn with PHYFUM. We implemented four different crypt division models in PHYFUM, and found we have signal in simulated data to detect them.
Building on previous work, we developed a mathematical model using methylation in CpGs that stochastically switch over time (fCpGs). Because this is happening in a large number of sites and rapidly enough, we have resolution to see evolution in normal tissue
