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Sreeganga Chandra Lab at Yale









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This work was also recognized by Alzforum! Read more here: www.alzforum.org/news/researc...
Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th
16d
10mo
Had a wonderful time discussing Parkinson's disease research at the World Parkinson's Congress 2026! PhD candidate @leah_harmon13 presented her work on synuclein and Multiple Systems Atrophy
See also this great write-up from @yaleschoolofmed.bsky.social about this work! medicine.yale.edu/news-article...
Had a wonderful & engaging meeting at Grand Challenges in Parkinson's disease earlier this month! It was good to see lab alumni Jamie and Mike @hndlab.bsky.social !
It was an honor for PhD students @mallnutt.bsky.social and @leaheharmon.bsky.social to be part of the Connecticut contingent at last week's Parkinson's Policy Forum Hill Day run by the Michael J Fox Foundation and @apdaparkinsons.bsky.social to advocate for funding for Parkinson's research!
Our paper exploring the link between cognitive deficits and GBA mutations in Parkinson's disease is out now in Nature Communications. Congratulations to @vidyadharadj.bsky.social and all of the authors on the success of their hard work! www.nature.com/articles/s41...
16d
CONGRATS 🎉 to @yaleneuro.bsky.social's Sreeganga Chandra (@schandralab.bsky.social), Janghoo Lim (@limlabyale.bsky.social), & Stephen Strittmatter on receiving funding from the Blavatnik Family Foundation 💰 for their innovative research in the field of #neuroscience! 🧠 More 👇
8mo
Earlier this month, this exciting paper from previous PhD student in the lab, Sofia, came out! Take a look at her exciting work characterizing lipofuscin in aging and Neuronal Ceroid Lipofuscinosis! link.springer.com/article/10.1...
8mo
8mo
8mo
Sreeganga Chandra Lab at Yale
2mo
Sreeganga Chandra Lab at Yale
16d
Sreeganga Chandra Lab at Yale
Lipofuscin accumulates in the brain with age and neurodegeneration. But what is it, where does it come from, and where does it go? The @schandralab.bsky.social built a lipofuscin brain atlas and shed light on its composition.
Sreeganga Chandra Lab at Yale
Sreeganga Chandra Lab at Yale
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, compos...
link.springer.com
Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis - Acta Neuropathologica
Sreeganga Chandra Lab at Yale
Sreeganga Chandra Lab at Yale
Yale Neuroscience
Sreeganga Chandra Lab at Yale
7d
Accumulation of a biological material called lipofuscin is associated with aging and neurodegeneration. A new study uncovers a driver of this process.
medicine.yale.edu
How Waste Build-Up in the Brain Occurs in Aging and Neurodegeneration
Yale Neuroscience
Breakthrough ideas need more than a laboratory—they need a clear path to real-world impact. Since 2017, Yale University and the Blavatnik Family Foundation have partnered to accelerate promising disco...
ventures.yale.edu
Blavatnik Fund for Innovation at Yale to Support 12 Life Sciences Projects in 2026 Spanning Oncology, Diagnostics, Neurology, Kidney and Liver Disease | Yale Ventures
Earlier this month, this exciting paper from previous PhD student in the lab, Sofia, came out! Take a look at her exciting work characterizing lipofuscin in aging and Neuronal Ceroid Lipofuscinosis! link.springer.com/article/10.1...
www.alzforum.org
16d
Lipofuscin Ingredients Tie Development to Degeneration | ALZFORUM
Lipofuscin accumulation in aging and CLN1 is associated with deficient de-S-acylation, lyso-mitochondrial dysfunction, and lipid dyshomeostasis - Acta Neuropathologica
Lipofuscin is an autofluorescent material that accrues in brain tissues with age and in Neuronal Ceroid Lipofuscinosis (NCL), a neurodegenerative disease with pediatric onset. The distribution, compos...
link.springer.com
GBA, a major gene for Parkinson’s disease and dementia with Lewy bodies, is associated with increased risk of developing dementia. Here, we demonstrate that GBA mutations in mice contribute to cognitive deficits through α-synuclein-independent mechanisms that impact synaptic vesicle endocytosis.
www.nature.com
Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies - Nature Communications
New findings reveal motor and cognitive deficits arise through separate mechanisms in Parkinson’s disease, challenging previous thinking.
medicine.yale.edu
How Gene Mutations Drive Dementia in Parkinson’s Disease
Sreeganga Chandra Lab at Yale