We develop a new TMS targeting algorithm and test it in an open label trial in a treatment-resistant depression population with high comorbidities. Preprints by @rubykong92.bsky.social Phern-Chern Tor
1. doi.org/10.1101/2025...
2. doi.org/10.64898/202...
Our new approach ...
I always assumed that brain function had to line up with cytoarchitectonics.
It turns out I was wrong.
Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams.
www.biorxiv.org/content/10.6...
Thomas Yeo
Our latest work looking at the neuroanatomical basis of impulsivity in youth is out now in Molecular Psychiatry!
Evan Gordon
Incredibly excited that the lab's first papers is now published! We use AI to simultaneously predict multiple neurodegenerative disease diagnoses from plasma proteomics. Congrats @anlijuncn.bsky.social !
#MedSky #neuroskyence #neurosky #alzsky #compneuro #ai #datascience #bioinformatics #neurology
Researchers led by Jacob Vogel and @anlijuncn.bsky.social from 🇸🇪 @lund-university.bsky.social, with @biofinder.bsky.social and @neuroproteome.bsky.social have developed an #AI model to detect different neurodegenerative diseases like #Alzheimers and Lewy body disease from a single blood sample.
Molecular Psychiatry - Neuroanatomy reflects individual variability in impulsivity in youth
New paper in Nature Aging led by PhD student Lina Lu! We mapped how APOE ε4 and APOE ε2 shape molecular changes in blood and cerebrospinal fluid across Alzheimer’s disease. www.nature.com/articles/s43...
If you want to learn proteomics signatures of APOE genetic variants on a massive sample from multi-chort, you should not miss this tour de force!
Huge congrats to Lu Lina and Niklas!
Elvisha Dhamala
Jake Vogel
Lijun An
Healthcare in Europe
New paper in Nature Aging led by PhD student Lina Lu! We mapped how APOE ε4 and APOE ε2 shape molecular changes in blood and cerebrospinal fluid across Alzheimer’s disease. www.nature.com/articles/s43...
Our work is now out in @natmed.nature.com www.nature.com/articles/s41... We developed a state-of-the-art AI-proteomics model for diagnosing multiple neurodegenerative diseases from blood plasma. ProtAIDe-Dx now outperformed both classic machine learning models and even foundation models like TabPFN!
Lijun An
www.nature.com
Apolipoprotein E (APOE) is the strongest genetic influence in Alzheimer’s disease (AD). Compared to the most frequent allele, ε3, the ε4 allele increases AD risk, and the ε2 allele is protective. Here...
The symptom profiles of different neurodegenerative diseases often overlap, and diagnosing age-related cognitive symptoms is complex. A patient may have multiple overlapping disease processes in the brain at the same time.
healthcare-in-europe.com
Apolipoprotein E (APOE) is the strongest genetic influence in Alzheimer’s disease (AD). Compared to the most frequent allele, ε3, the ε4 allele increases AD risk, and the ε2 allele is protective. Here...
Can AI reveal risk & co-pathology of multiple neurodegenerative diseases from a single blood sample? We explored AI-based diagnostic power on high rank plasma proteomics (N=17,170). www.medrxiv.org/content/10.1... #neuroskyence #neurosky #Alzheimer #compneuro #AI #datascience #neurology
Co-pathology is a common feature of neurodegenerative diseases that complicates diagnosis, treatment and clinical management. However, sensitive, specific and scalable biomarkers for in vivo pathologi...
