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by @danabra.mov
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by @danabra.mov
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by @jimpick.com
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by @atsui.org
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Such a fabulous work ⬇️ the more I read it, the better it gets! Katrine and team led this trojan, brilliant work demonstrating how O-glycosylation selectively regulates LRP1 ligand binding and response 🙏 We looked at why these CRs (GALT11) O-glycans are hyposialylated 🤔 doi.org/10.1126/scia... 🧵⬇️
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Elisa Fadda
Next time you hear 'glycans are just a fancy protein decoration' 😱 show them this fabulous work led by Katrine Schjoldager and team at the CGR 🇩🇰 with us 🇬🇧 showing how The ligand preference of LRP1 is regulated by O-glycans Out now www.science.org/doi/10.1126/... 🧵1/10 ⬇️
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GALNT11-mediated O-glycans modulate LRP1 uptake of tau and Aβ, unveiling glycan-driven mechanisms in neurodegenerative pathways.
www.science.org
The ligand preference of LRP1 is regulated by O-glycans
GlycoShape